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Pathophysiology
q
Rare
<1% of all hypertension.
q
Aldosterone secretion.
Causes
1. Adrenal
adenoma (Conn’s syndrome):
60%
>> ♀
2. Bilateral
adrenal hyperplasia:
30%
>> ♂
Clinical
Features
Hypertension,
Hypokalemia
Investigations
1.
P-aldosterone.
Not
suppressed with saline infusion / fludrocortisone.
2. ¯
PRA.
3. Hypokalemic
alkalosis & U-K+ loss.
Treatment
q
Adenoma
à
Surgery.
q
Hyperplasia
à Spironolactone (aldosterone antagonist).
q
Hypertension
à
Ca+ channel blockers/ ACE inhibitors.
written
by:
Khalid Bin Yaroof. FMHS, UAE University.
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